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pentobarbital will minimize the level or effect of ramelteon by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Minimal/Importance Unidentified.Barbiturates can induce hepatic microsomal enzymes resulting in enhanced metabolism and lessened anticoagulant response of oral anticoagulants (eg, warfarin, acenocoumarol, dicumarol, and phenproco